Synthesis of Amino Acid-Derived Cyclic Acyl Amidines for Use in β-Strand Peptidomimetics
نویسندگان
چکیده
منابع مشابه
Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics
The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at Cα, such amide bond surrogates need a chiral moiety. Here the asymmetric synthesis of a set of 24...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2007
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo062664i